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Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi |
2016, Cilt 30, Sayı 2, Sayfa(lar) 075-078 |
[ Turkish ] [ Tam Metin ] [ PDF ] |
Effects of Flunixine Meglumine, Diclofenac Sodium, Metamizol Sodium and Carprofen on Oxidative Stress in Rats Subjected to Laparotomy |
Nuh KILIÇ1, L. Didem KOZACI2 |
1Adnan Menderes Üniversitesi, Veteriner Fakültesi, Cerrahi Anabilim Dalı, Aydın, TÜRKİYE 2Yıldırım Beyazıt Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Ankara, TÜRKİYE |
Keywords: Oxidative stress, laparotomy, NSAIDs, rat |
The aim of this study was to determine the effects of nonsteroid antiinflammatory drugs on oxidative stress in rats subjected to laparotomy. Rats (n=50) were divided into five equal groups. Control group (n=10, Group I) received physiological saline whereas Groups II-V (n=10 in each) received metamizole (50 mg/kg), flunixin meglumine (2.5 mg/kg), carprofen (2.5 mg/kg), or diclofenac (2.5 mg/kg) by intraperitoneal injection for 5 days following the operation. On postoperative day 6, blood samples were obtained; levels of malondialdehyde (MDA) and nitric oxide (NO) in serum, and erythrocyte glutathione (GSH), catalase levels were determined. NSAIDs caused a decrease in MDA, NO and GSH levels, whereas catalase levels increased with NSAID treatment. In conclusion, NSAIDs may have additional beneficial effects to their anti-inflammatory effects by diminishing the oxidative stress.
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