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Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi
2021, Cilt 35, Sayı 3, Sayfa(lar) 158-165
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Investigation of the Effect of Rutin on Oxidative Stress, Apoptosis and Inflammation Parameters in Rats with Deltamethrin Induced Gastric Toxicity
Mustafa İLERİTÜRK, Tuba DOĞAN, Emine SATICI
Atatürk Üniversitesi, Veteriner Fakültesi, Biyokimya Anabilim Dalı, Erzurum, TÜRKİYE
Keywords: Apoptosis, deltamethrin, ınflammation, oxidative stress, rutin

Deltamethrin (DLM) is a highly effective insecticide widely used to control insects and various pests. While DLM is used to control insects, it can also cause serious toxic effects as a result of unconscious use. Rutin (RUT) is a powerful natural antioxidant molecule obtained from citrus fruits and has low toxic effects and non-oxidation properties. This study was designed to determine the protective effects of RUT against gastric toxicity caused by DLM in rats. Rats were divided into 5 groups and experimental procedure carried out for 28 days. DLM (1.28 mg/kg) and RUT (25 and 50 mg/kg) were administered orally to animals. The levels of reduced glutathione (GSH), malondialdehyde (MDA), one of the lipid peroxidation products, and superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) activities were determined in the gastric tissue. mRNA transcript levels of inflammation markers such as tumor necrosis factor alpha (TNF-α), nuclear factor (erythroid-derived 2)-related factor 2 (Nrf-2) and nuclear factor kappa B (NF-kB) and apoptotic markers such as cysteine aspartate-specific protease caspase-3 (caspase-3) and of signal transducer and activator of transcription-3 (STAT3) were measured. According to our results it was determined that RUT administration reduced the oxidative damage caused by DLM and had regulatory effects on apoptosis and inflammation markers.

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