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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
2006, Cilt 20, Sayı 2, Sayfa(lar) 143-147
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Euthyroid Sick Syndrome in Cases with COPD Attack and Evaluation of The Response of Thyroid Function Tests to Attack Therapy
Gamze KIRKIL, Figen DEVECİ, Teyfik TURGUT, Suat TÜRKOĞLU, Mehmet Hamdi MUZ
Fırat Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Elazığ-TÜRKİYE
Keywords: COPD, ESS, Arterial blood analyses

Euthyroid sick syndrome (ESS) describes the abnormalities of thyroid function in critically ill patients. We aimed to investigate the incidence of ESS in cases with COPD attack, the levels of thyroid hormone during stable period, and the relation between the Thyroid function tests (TFT) and arterial blood analyses (ABA).

Serum free T3 (fT3), fT4, total T3 (TT3), TT4, TSH levels, and ABA of 39 cases with COPD attack, and 20 healty cases were analyzed. In ESS (+) patients these parametres were again measured after attack therapy.

ESS was determined in 29 (74.35%) COPD cases. There was a significant difference in PaO2 and TT3 levels between control and ESS (-) COPD group (p<0.001, p=0.003, respectively), and also in PaO2, PaCO2, O2 saturation, TT3, fT3 levels between control and ESS (+) COPD group (p<0.001, p=0.012, p=0.004, p<0.001, p=0.025, respectively). There was no difference in ABA parameters between ESS (+) and ESS (-) COPD groups (p>0.05), but sT3, TT3 levels were significantly low in ESS (+) COPD group (p=0.001, p<0.001, respectively).

A significant increase in TT3, sT3, O2 saturation levels of ESS (+) COPD group during stable period was observed (p<0.046, p<0.025, p<0.034 respectively).

In ESS (+) group, there was a negative correlation between fT3, TT3 and PaCO2 (p=0.025, r= -,415 ve p=0.016, r= -,443 respectively), a positive correlation between TT4 and PaO2 (p=0.023, r=0.421), and a negative correlation between TSH and O2 saturation (p=0.029, r=-0.407), during attack. There was no correlation between TFT and ABA parametres in stable period (p>0.05).

In conclusion, thyroid function abnormalities may occur frequently in COPD cases, but we should not hurry to interfere these abnormalities during attack therapy. Serial analyses of thyroid levels can manage therapy more exact.


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