Recent studies suggest that increased levels of lipid peroxidation and glycosylation affect blood cells negatively and consequently cause to vasculer impairements in postmenopausal diabetics. This study was carried out to investigate the effects of estradiol (E₂) and vitamin E on some haematological parameters in rats with ovariectomy and diabetes. For this purpose, 70 female Wistar albino rats of 200 g body weight were allocated to 7 groups, i.e. 1. Control group, 2. ovariectomy+diabetes group, ovariectomized rats were made diabetes by intraperitoneal administered streptozotocin (45 mg/kg body weight). group 3. ovariectomy+diabetes+E₂ group, 4. ovariectomy+diabetes+E₂+Vitamin E group, 5. ovariectomy group, 6. ovariectomy+E₂ group, 7. ovariectomy+E₂+Vitamin E. Groups (3,4,6,7) were administered 17-β estradiol subcutan (40 µg/kg/day), groups (4,7) vitamin E (dl-α-tocopheryl acetat) intraperitoneal (100 mg/kg/day) for 28 days. Blood samples were collected from rats into tubes with EDTA, in order to determination some blood parameters. According to the findings of this study, when compared with group 5, leukocyte count (WBC) (p<0.001), hematocrit value (p<0.01), and mean corpusculer volume (MCV) (p<0.001) were found to increase significantly in group 2 due to the effects of diabetes. When compared with group 2, the hematocrit value and MCV (p<0.05) decreased significantly in groups 3 and 4 due to the effects of E₂ and vitamin E. When compared with group 3, hematocrit value and MCV (p<0.05) decreased significantly in group 4 due to the effects of vitamin E. When compared group 5, hematocrit value and MCV (p<0.01) decreased significantly in group 6. No statistically significant differences were found in erythrocyte count, mean corpusculer hemoglobin (MCH), mean corpusculer hemoglobin concentration (MCHC) and hemoglobin amount in all groups.

In conclusion the results of the study suggest that the administration of E₂ and vitamin E to ovariektomized and diabetic rats can return the increased WBC, hematocrit value and MCV to normal levels.