Objective: Patients with primary hyperparathyroidism (PHPT) have been shown to have an increased risk of cardiovascular mortality, but the mechanisms underlying this increased risk have not yet been elucidated. This research aimed to investigate the changes in preoperative and postoperative serum calcium, serum parathormone, blood platelet count and mean platelet volume (MPV) in patients who underwent parathyroidectomy for PHPT.

Materials and Methods: Four male (11.8%) and 30 female (88.2%) patients who underwent parathyroidectomy for PHPT were included in the study. Preoperative and postoperative sixth-month blood samples were collected, parameters associated with atherosclerosis, namely the serum calcium, serum parathormone, blood platelet count and MPV values were compared.

Results: In this study, there was a statistically significant decrease in the serum calcium level (p<0.001), serum parathormone level (p<0.001), blood platelet count (p<0.001), and MPV (p=0.002) at the sixth month after parathyroidectomy compared to the preoperative period.

Conclusion: In patients with PHPT, successful parathyroidectomy reduces the risk of cardiovascular diseases by providing a decrease in blood parameters associated with atherosclerosis.