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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
2022, Cilt 36, Sayı 2, Sayfa(lar) 161-166
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The Effects of Metformin, Letrozole, and Atorvastatin on the Liver and Kidneys in Rat Endometriosis
Tansel SAPMAZ1, Sude TOPKARAOĞLU1, Gülfidan COŞKUN2, Muhammetnur TEKAYEV1, Sait POLAT2, Ekrem SAPMAZ 3
1Sağlık Bilimleri Üniversitesi, Hamidiye Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, İstanbul, TÜRKİYE
2Çukurova Üniversitesi, Tıp Fakültesi, Histoloji Embriyoloji Anabilim Dalı, Adana, TÜRKİYE
3Sağlık Bilimleri Üniversitesi, Adana Şehir Hastanesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Adana, TÜRKİYE
Keywords: Metformin, letrozole, atorvastatin, endometriosis, liver, kidney

Objective Endometriosis is a disease that develops as a result of the growth of the endometrial layer of the uterus in another part of the body. In addition, inflammation resulting from endometriosis causes distant organ damage in tissues such as the liver and kidneys. In this study; we aimed to investigate the effects of metformin, letrozole, and atorvastatin on the liver and kidneys in experimentally induced ovarian and peritoneal endometriosis in rats.

Materials and Methods: 35 rats were randomly divided into 5 groups. Group 1 was determined as the control group. Endometriosis was formed in Group 2, 3, 4, and 5 rats. Group 3 received 100 mg/kg/day/oral metformin, Group 4 received 0.1 mg/kg/day/oral letrozole, Group 5 received 2.5 mg/kg/day/oral atorvastatin. At the end of 28 days, the liver and kidneys were removed and examined histopathologically.

Results: It was determined that mild edematous and hemorrhagic areas were formed in the liver tissues of rats for which the endometriosis model was created. The presence of these areas was significantly reduced, and the classical liver lobule structure preserved its integrity when the treatment groups were compared with endometriosis modeled rats. Tubular epithelial vacuolization, tubular epithelial detachment, and capillary congestion were noted in renal tissue samples of rats with an endometriosis model. A decrease in these pathological damages was observed in renal tissue samples of the treatment groups.

Conclusion: In this study; metformin, letrozole, and atorvastatin were found to have anti-inflammatory effects on liver and kidneys in experimentally induced peritoneal and ovarian endometriosis.


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