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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
2024, Cilt 38, Sayı 3, Sayfa(lar) 255-260
[ Turkish ] [ Tam Metin ] [ PDF ]
Histopathological Evaluation of Helicobacter pylori Infection in Children
Esra ERDOĞAN1, Songül YERLİKAYA KAVAK2, Tarık SALCAN3, Mehmet Mustafa ERDOĞAN4
1Harran University, Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, Sanliurfa, TURKIYE 2Malatya Training and Research Hospital, Department of Pathology, Malatya, TURKIYE
3Mersin Provincial Health Directorate, Public Health, Mersin, TURKIYE
4Şanlıurfa Training and Research Hospital, Department of Histology and Embryology, Sanliurfa, TURKIYE
Keywords: H. pylori, childhood, histopathology, intestinal metaplasia, lymphoid follicle

Objective: Helicobacter pylori infection, which is among the most common childhood infections, is frequently seen around the world, especially in developing countries. H. pylori can cause infection, gastritis, ulcers and gastric cancer in infected individuals. Morbidity and mortality can be prevented with early diagnosis and treatment. This study aimed to histopathologically evaluate the frequency of H. pylori in the pediatric age group (3-18 years old) in Malatya province and examine the accompanying pathologies.

Materials and Methods: In the study, the tissues of 187 pediatric patients who applied to Malatya Training and Research Hospital Pediatric Gastroenterology clinic between January 2017 and December 2022 and underwent upper gastrointestinal system endoscopy for any reason between the ages of 3-18 were retrospectively examined. The presence and severity of H. pylori, chronic inflammation, activity, atrophy, intestinal metaplasia and lymphoid follicles were evaluated histopathologically in the cases. Bacterial density was evaluated and reported as absent (-), low (+), medium (++) and high (+++) according to the Sydney classification.

Results: A total of 187 biopsy samples, 103 from girls and 84 from boys, were included in the study. Among 187 patients, the number of H. pylori positive patients was 95 (50.8%), 48 of which were girls and 47 were boys. The frequency of H. pylori in the 3-10, 11-15, 16-18 age ranges was determined as 55.0%, 46.9%, 48.0%, respectively. A statistically significant relationship was found between the presence of H. pylori and activity, inflammation and lymphoid follicle (p<0.01).

Conclusion: H. pylori infection continues to be an important health problem in children, especially in developing countries.


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