Objective: Recently, changes in hemogram and biochemical blood parameters in schizophrenia patients have been associated with disease symptoms. We aimed to investigate triglyceride-glucose index and triglyceride/hdl ratio in patients with schizophrenia who had committed crimes.

Materials and Methods: The study included 49 healthy controls and 51 patients diagnosed with schizophrenia who had committed crimes. A sociodemographic and clinical data form was applied to all participants and routine blood tests were evaluated after an average 12-hour fasting period. Fasting Triglyceride-Glucose index ln[fasting triglyceride (mg/dl) x fasting plasma glucose (mg/dl)/2] value and TG/HDL level were calculated.

Results: When the types of crimes committed by the case group were analyzed, it was found that 10 (19.6%) were minimally violent, 20 (39.2%) were moderately violent, 16 (31.4%) were moderately serious and 5 (9.8%) were seriously violent. While no significant difference was found between the groups in terms of WBC, Hgb, Plt, Glucose and AST values, Urea, Creatine and ALT parameters were significantly higher in the control group. No significant difference was found between the groups in terms of Triglyceride-Glucose index and Tg/HDL ratio (p>0.05). There was a significant positive correlation between crime severity and disease duration (r=0.439, p=0.001). There was a significant negative correlation between crime severity and Tg/HDL ratio (r=-0.387, p=0.005).

Conclusion: We suggest that there is a negative correlation between the severity of the crime andTg/HDL ratio in patients with schizophrenia and that this parameter can be used in the forensic follow-up of these patients who have committed crimes. Additionally, the exclusion of female patients limits the generalizability of the findings, and further research including female participants is needed to assess gender-related variations in these parameters. The clinical implications of these findings suggest potential biomarkers for risk assessment, while the forensic aspect underscores the importance of monitoring metabolic health in criminalized schizophrenia patients.