Objective: Atrial fibrillation (AF) is the most common sustained arrhythmia. AF is a serious health problem since it causes discomfort, heart failure, and strokes in patients. This study aims to identify the possible role of eNOS G894T polymorphisms in AF incidence.

Materials and Methods: Seventy-three individuals were included in the study, with a mean age of 63.47±9.10, who received an electrocardiogram (ECG) at the Elazığ Training and Research Hospital, Cardiology Department. Ninety-two individuals with a mean age of 60.71±9.14 who were confirmed to have no heart condition were included as the control group. Genomic DNA from both the control and AF groups was isolated from whole blood samples. eNOS G894T polymorphism was detected using real-time PCR analysis. This study was conducted between September and December 2018. Ethical approval was obtained from the Ethics Committee of University, dated 04/09/2018 and numbered 279476.

Results: A statistically significant difference in hypertension was found between the AF patient and control groups (p<0.023); however, no significant differences were observed for diabetes, smoking, and body mass index. The analysis of the G894T eNOS polymorphism revealed that the TT genotype was significantly more frequent in the patient group (59.27%) compared to the control group (3.27%) (p<0.0001), while the GG genotype was predominantly observed in the controls (63.04%). Additionally, the T allele frequency was markedly higher in patients than in controls (77.93% vs. 20.11%; OR: 14.02, 95% CI: 9.6-20.45; p<0.0001).

Conclussion: These findings indicate a strong association between the T allele and TT genotype of the G894T eNOS polymorphism and the disease.