Objective: Serum atherogenicity index is a scoring tool that is used to quantitatively assess risk. Serum atherogenicity index aims to prevent deterioration in thyroid dysfunction and predict atherosclerotic risk.

Materials and Methods: A total of 200 individuals (100 hypothyroid, 50 hyperthyroid and 100 control group) were included in the study [a=0.05 ß=0.10 1-ß=0.90 R (Sample Allocation= 2)]. Age, gender, height and weight values of the patients were recorded. Blood glucose, hemogram values, HbA1c levels, renal and liver functions, serum lipid levels were recorded from biochemistry data. Serum atherogenicity indices were calculated as the ratio of plasma triglyceride level to HDL (high density lipoprotein) level. Data were analyzed in SPSS.

Results: Mean TG (triglyceride) and LDL (low density lipoprotein) levels were higher in both hypothyroidism and hyperthyroidism groups compared to the control group (X2=256.367 p=0.003; X2=266.976 p=0.003). Although the mean HDL level was higher in the hypothyroid and hyperthyroid groups compared to the healthy group, it was not statistically significant alone (X2=88.939 p=0.130). TG/HDL was calculated as 3.1 in hypothyroid patients and 3.2 in hyperthyroid patients. When hyperthyroidism and hypothyroidism patients were compared with the control group, atherogenicity index was higher in thyroid dysfunction; the difference was statistically significant (KW=39.49; p=0.001). The serum atherogenicity index was considered to be a reliable tool for the assessment of cariovascular risk in thyroid dysfunction.

Conclusion: Coronary artery disease risk was higher in individuals with thyroid dysfunction. The use of serum atherogenicity index for early recognition of cardiovascular risk may be an easily applicable and supportive parameter in clinical practice.