Objective: One of the important public health measurement is migrant vaccination. Therefore, the reasons for vaccine refusal among immigrants are worth investigating. The study aims to determine vaccine hesitance of Syrian migrants’ and related factors.

Materials and Methods: The population of this study consists of Syrian immigrants living in the province of Elazığ. The median (minimum-maximum) values of the data were given, and Mann-Whitney U, Kruskal-Wallis tests were used for statistical evaluations. p<0.05 was accepted as statistical significance.

Results: Forty-four point three percent of the participants were male and 55.3% of them were married. The average age of the participants in the study was 35.00 years. Most of the participants declared to received information about the vaccine from the health staff. Two hundred and three of them who had the vaccines were included in the vaccination calendar because they believed the vaccine would protect them against diseases. Sixty-eight of them were not vaccinated because of the influence of their family elders. The vaccine hesitancy scale score and 1st sub-scale score among women were significantly higher than those of men. As the educational status and economic status increased, the vaccine hesitancy scale score and the scores of all sub-scales decreased significantly.

Conclussion: In this study, vaccine hesitancy scale and subscale scores were positively correlated with age, number of children, and duration of stay among immigrants living in Turkey. The findings suggest that the primary reason for vaccine refusal is a perceived sense of insecurity.