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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi |
2012, Cilt 26, Sayı 2, Sayfa(lar) 093-096 |
[ Turkish ] [ Tam Metin ] [ PDF ] |
Granulosa Cell Tumor of the Ovary in a Postmenopausal Patient: Report of a Case and Review of the Literature |
Mine GENÇ1, Berhan GENÇ2, Berrrin KORKUT3, Arzu TURAN3, Sefa KURT4 |
1Şifa Hastanesi, Kadın Hastalıkları ve Doğum, Anabilim Dalı, İzmir, TÜRKİYE 2Şifa Hastanesi, Radyoloji Anabilim Dalı, İzmir, TÜRKİYE 3Şifa Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, İzmir, TÜRKİYE 4Ege Doğumevi, İzmir, TÜRKİYE |
Keywords: Granulosa cell tumor, ovary, postmenopausal vaginal bleeding |
Granulosa cell tumours (GCT) are uncommon sex cord-stromal tumours of the ovary, and comprise
approximately 2-3% of all ovarian malignancies. These tumours characteristically have a low
malignant potential, and have slow growth rates. They are hormonally active stromal cell
neoplasms that can secrete sex steroids such as estrogen. Serum tumor markers such as estradiol
and inhibin are used for diagnosis of GCT. Low serum level of FSH may be useful as a diagnostic
marker in postmenopousal period. Patients may present with vaginal bleeding caused by
endometrial hyperplasia or uterine cancer as a result of prolonged exposure to tumor-derived
estrogen. In this case report, a patient with a painless mass of right ovary and atypical endometrial
hyperplasia was presented. Frozen examination of the removed right ovarian mass revealed the
diagnosis of granulosa cell tumor.
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