[ Ana Sayfa | Editörler | Danışma Kurulu | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | E-Posta ] |
Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi |
2013, Cilt 27, Sayı 2, Sayfa(lar) 069-073 |
[ Turkish ] [ Tam Metin ] [ PDF ] |
The Effect of Short-Term Antidepressant Treatment on Serum Levels of Nesfatin-1, Nitric Oxide and Ghrelin in Patients with Major Depressive Disorder |
Sermin ALGÜL1, Fazilet ERMAN2, Bilge KARA3, Murat KARA4, Orhan ERMAN5 |
1Fırat Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Elazığ, TÜRKİYE 2Fırat Üniversitesi, Elazığ Sağlık Yüksekokulu Elazığ, TÜRKİYE 3Harput Devlet Hastanesi, Psikiyatri Kliniği, Elazığ, TÜRKİYE 4Fırat Üniversitesi, Tıp Fakültesi, Genetik Anabilim Dalı, Elazığ, TÜRKİYE 5Fırat Üniversitesi, Fen Fakültesi, Biyoloji Bölümü, Elazığ, TÜRKİYE |
Keywords: Nesfatin-1, NO, ghrelin, major depressive disorders, venlafaxin |
Objective: Recent studies have shown that major depressive disorders (MDD) have important
effects on nesfatin-1, nitric oxide (NO) and ghrelin hormones. To understand the possible roles of
nesfatin-1, NO and ghrelin on effectiveness of MDD treatment, the effects of short-term
antidepressant venlafaxine treatment on these parameters in patients with MDD were evaluated.
Material and Methods: Sixty subjects (20 MDD patients and 40 healthy controls) enrolled in the study. Venlafaxine (225 mg/day for 3 months) was given to patients. Fasting blood samples were taken at onset of the study and at the end of the 3 months. Biochemical parameters, serum ghrelin, nesfatin-1 and NO were analysed. Results: After 3 months treatment, the patients prognosis, evaluated by the HAM-D scale, improved from 36.6±1 to 15.9±0.6 (P=0.04). Nesfatin-1 (p=0.001) and ghrelin (P=0.001) levels decreased and NO levels increased significantly (P=0.04) after treatment in MDD patients. Conclusions: Decreased nesfatin-1, and increased NO levels comparing to their normal levels after venlafaxine application could be an important criteria to evaluate patients' response to treatment and also prognosis in addition to the improvement of HAM-D scales. |
[ Turkish ] [ Tam Metin ] [ PDF ] |
[ Ana Sayfa | Editörler | Danışma Kurulu | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | E-Posta ] |