[ Ana Sayfa | Editörler | Danışma Kurulu | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | E-Posta ]
Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
2015, Cilt 29, Sayı 1, Sayfa(lar) 011-018
[ Turkish ] [ Tam Metin ] [ PDF ]
Review of Interleukin-6 and Interleukin-18 Levels in Patients Diagnosed with Chronic Hepatitis B
Müge ÖZGÜLER1, Handan AKBULUT2, Ayhan AKBULUT3
1Elazığ Eğitim Araştırma Hastanesi, Enfeksiyon Hastalıkları Kliniği, Elazığ, TÜRKİYE
2Fırat Üniversitesi, Tıp Fakültesi, İmmünoloji Anabilim Dalı, Elazığ, TÜRKİYE
3Fırat Üniversitesi, Tıp Fakültesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Elazığ, TÜRKİYE
Keywords: Chronic hepatitis B, proinflammatory cytokine, interleukin 6, interleukin 18

Objective: The hepatitis B virus (HBV) is a DNA virus of the Hepadnaviridae family. The course of infection depends on the patient's immune response. Interleukin 6 (IL-6) and Interleukin-18 are significant cytokines for immune response. Chronic hepatitis B patients may exhibit insufficient immune response against the hepatitis B virus. There may be differences in interleukin 6 and interleukin 18 (IL-8) levels between patients and healthy controls. In this study, we aimed to assess the relationship between the level of IL-6 and IL-18, and chronicity of the disease in patients diagnosed with chronic Hepatitis B virus infection.

Materials and Methods: Sixty-three treatments-naive patients diagnosed with chronic active hepatitis B infection who applied to our clinic between June 2010 and May 2011 were enrolled in the study. 5 mL of blood was collected from each patient and IL-6 and IL-18 levels were examined by the ELISA method.

Results: The IL-6 and IL-18 levels of the control group were compared with those of the subjects in the patient group. The Mann-Whitney U test was used to evaluate the control group and the patient group, and it was found that the IL- 6 level was statistically higher in the patient group (p 0.011). There was no significance for IL-18 levels between the control group and the patient group with low viral load. However, we detected a statistically significant elevation in IL-18 levels of patient groups with high viral load compared to the control group.

Conclusion: The response to IL-6 and IL-18 can be lower in patients, and the receptor resistance against IL-6 and IL-18 may have developed. This may be the reason for chronicity.


[ Turkish ] [ Tam Metin ] [ PDF ]
[ Ana Sayfa | Editörler | Danışma Kurulu | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | E-Posta ]