Diabetes, is a group of metabolic diseases, causing metabolic disorders decreasing the lifespan and quality of life because of insulin deficiency.

The purpose of the study was to check apelin and chemerin levels on the 7th, 14th, and 21st days, respectively in rats made diabetic with Streptozotocin. Accordingly, it was also investigated if there was any relationship between insulin resistance of Adipokins and Beta cell functions to exhibit relation inbetween apelin and chemerin levels and diabetes.

Five weeks old, 37 male Spraugue Dawley rats were used in study. Rats were divided into 2 groups. 1. Control Group (n=7) fed by standard method. 2. Diabetic Group (n= 30); rats were initially given 65 mg/kg intraperitoneal single dose Streptozotocin and after 3 days, blood glucose levels measured from tail veins showed over 200 mg/dL and rats were confirmed diabetics (DM). DM group were divided into 3 sub-groups. First sub-diabetic group ended on 7th day (DM7), second sub-diabetic group ended on 14th day (DM14), and third sub-diabetic group ended on 21st day (DM 21) and decapitated and blood samples were taken.

In all diabetics groups, compared to control group, no significant differences were detected in apelin, chemerin, insulin, C-peptid, HbA1-C, LDL, uric acid parameters.

Despite there was no significant change between control and diabetics, there were some numerical increase between sub-diabetics groups serum levels apelin, chemerin insulin, C-Peptid, HbA1-C, LDL and uric acid based on day and serum glucose, glucose 1, HDL, triglyceride, cholesterol, and HbA1C levels had significant changes (P<0.05).

Results showed that apelin and chemerin levels in blood serum increased insignificantly (P>0.05) by time.