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Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi
2021, Cilt 35, Sayı 2, Sayfa(lar) 098-102
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Effect of Gingko Biloba Extract (Egb761) Supplementation on Hemato-Biochemical Parameters Following Acute Treadmill Exercise in Rats
Yasemin ÇINAR1, Ruhi KABAKÇI2, Ali ŞENOL3
1Afyonkarahisar Health Sciences University, Faculty of Medicine Hospital, Physical Medicine and Rehabilitation Unit, Afyonkarahisar, TURKEY
2Kırıkkale University, Faculty of Veterinary Medicine, Department of Physiology, Kırıkkale, TURKEY
3Kırıkkale University, Faculty of Veterinary Medicine, Department of Biochemistry, Kırıkkale, TURKEY
Keywords: Biochemistry, exhaustive exercise, gingko biloba, hematological parameters

This study was aimed to investigate the effect of Gingko biloba extract (EGb761) on hemato-biochemical parameters following acute treadmill exercise in rats. Thirty-two male rats were divided into four groups with equal number of rats. The animals of control and exercise groups orally received 2 cc/kg bw 0.9% saline while EGb761 and EGb761+exercise groups received 100 mg/kg bw EGb761 by oral gavage for 5 days/week for 4 weeks. On the last day of experiment, the animals of the exercise groups were promoted to acute exhaustive exercise, and blood samples were collected by intracardiac puncture from all rats. Following the hematological analysis, plasma samples were separated for biochemical analysis. The results showed that exercise, EGb761 supplementation or both did not lead to alteration on red blood cells (RBC), packed cell volume (PCV), hemoglobin (HGB), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) (P>0.05). However, acute exhaustive exercise reduced mean corpuscular cell volume (MCV) in rats while increased red cell distribution width (RDW) (P<0.05). In addition, plasma alanine aminotransferase (ALT) activity, total cholesterol, and total protein levels did not change in any group (P>0.05), and alkaline phosphatase (ALP) activity was significantly increased in exercise groups while glucose and triglyceride levels were decreased (P<0.05). In conclusion, our results showed that acute exhaustive exercise affected MCV and RDW values, plasma ALP activity, glucose, and triglyceride levels. Gingko biloba extract supplementation ameliorated only the exercise-induced changes in ALP activity and RDW value. Therefore, it is suggested that the effects of usage after exercise or different doses of EGb761 should be investigated in the future comprehensive studies.

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