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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
2022, Cilt 36, Sayı 1, Sayfa(lar) 025-030
[ Turkish ] [ Tam Metin ] [ PDF ]
Effects of Local and Systemic Boric Acid Application on the Osseointegration Levels of Titanium Implants
Nedim GÜNEŞ1, Alihan BOZOĞLAN2, Serkan DÜNDAR2
1Dicle Üniversitesi, Diş Hekimliği Fakültesi, Ağız, Diş ve Çene Cerrahisi Anabilim Dalı, Diyarbakır, TÜRKİYE
2Fırat Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Anabilim Dalı, Elazığ, TÜRKİYE
Keywords: Boric acid, titanium implant, osseointegration, bone implant connection, bone implant contact

Objective: In this study, we aimed to investigate the effects of local and systemic boric acid (BA) application on the osseointegration of titanium implants in rat tibias.

Materials and Methods: The titanium implants were integrated surgically to the right tibias of a sample group of 32 rats. Rats were randomly divided into four treatment groups: controls (CNT) (n=8), local BA (LBA) (n=8), systemic BA (SBA) (n=8), and systemic and local BA (SLBA) (n=8) groups. Controls received no further treatment following implant surgery. In the LBA group, local BA was applied locally in the implant sockets, after which the implants were inserted in the sockets. In the SBA group, 8 mg/kg BA was applied intraperitoneally. In the SLBA group, local BA was applied locally in the implant sockets, after which the implants were inserted in the sockets; then, 8 mg/kg BA was applied intraperitoneally in a day. The experimental period lasted 28 days, after which the animals were euthanized and the implants collected, along with some surrounding bones from each rat.

Results: Bone–implant connection (BIC) ratios (%) were observed using the non-decalcified histologic method. In the SLBA and SBA groups, BIC ratios were high compared with the controls and the LBA group (p<0.05) (p=0.004 p=0.002 p=0.011 p=0.013). In the SLBA group, the BIC ratio was higher than in the SBA animals numerically but not statistically (p>0.05 p=0.38).

Conclusion: Within the limitations of this study, it may be concluded that systemic and systemic with local BA application could increase the osseointegration of titanium implants.


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