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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
2006, Cilt 20, Sayı 4, Sayfa(lar) 277-280
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An Investigation of the Levels of Antioxidants Vitamins ( A, E and C), Selenium in Serum and Glutathione Peroxidase (GSH-Px) in Erythrocytes of Goitre Patient's
Fikret KARATAŞ1, Uğur AŞKIN1, İhsan HALİFEOĞLU2, Emir DÖNDER3
1Fırat Üniversitesi, Fen-Edebiyat Fakültesi, Kimya Bölümü, Elazığ -TÜRKİYE
2Fırat Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Elazığ – TÜRKİYE
3Fırat Üniversitesi, Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Elazığ – TÜRKİYE
Keywords: Goitre, A, E, C vitamins, GSH-Px, Se and HPLC

In this study, the antioxidant vitamin (A, E and C) and selenium levels in the serum and GSH-Px activity in erythrocytes of 66 patients with goitre and 54 person taken as control group have been determined by HPLC and spectrophotometer, respectively.

It was obtained that the A, E and C vitamin and selenium levels of goitre patients were lower than those of control group (p<0.05) but GSH-Px activities were not significantly different (p>0.05). Finally, it was concluded that the decrease seen in the antioxidant activity, depending of the existence of free radicals, of goitre persons enables the possibility of using these antioxidant vitamins and selenium for treating goitre patients. Furthermore, these antioxidant vitamins and selenium may also be efficient to passivate the free radicals produced by this disease.


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