It was shown that many antioxidants decrease in Behçet’s disease (BD). Total antioxidant response (TAR), whose measurement method has been recently specified and developed, represents the total antioxidant properties of all antioxidants. This study aims to measure the antioxidant capacity in BD with TAR and to determine its relation with disease activity.

The study included 21 BD cases (10 active and 11 inactive) and 23 healthy volunteers as the control group. TAR and total peroxide (TP) were studied using appropriate methods and oxidative stress index (OSI) was calculated.

TAR level was 1,04±0,07 and 1,16±0,08 mmol Trolox eq./L in the BD group and in the control group, respectively; TP level was 13,4±4,5 and 7,72±1,86 µmol H202/L in the BD group and in the control group, respectively; OSI value was 1,45±0,52 and 0,67±0,18 Arbitrary Units in the BD group and in the control group, respectively. When compared to the control group, TAR level was significantly lower and TP and OSI levels were significantly higher in the BD group (p<0.001, for each). TAR level was negatively correlated with TP and OSI levels both in the BD group (r=-0.578, p<0.01 and r=-0.552, p<0.01, respectively) and the control group (r=-0.469, p<0.05 and r=-0.391, p<0.05, respectively). There was not any significant difference between active and inactive BD groups in terms of TAR, TP and OSI levels (p>0.05, for each).

TAR is an appropriate method that can be used to determine the antioxidant capacity in BD.