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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi |
2008, Cilt 22, Sayı 2, Sayfa(lar) 059-064 |
[ Turkish ] [ Tam Metin ] [ PDF ] |
Antioxidant Effects Of Omega-3 Fatty Acids on Experimental Formaldehyde Toxicity induced İnjury of Hippocampus |
İsmail ZARARSIZ1, İlter KUŞ 2, H.Ramazan YILMAZ3, Evren KÖSE2, Mustafa SARSILMAZ2 |
1Mustafa Kemal Üniversitesi Tayfur Ata Sökmen Tıp Fakültesi, Anatomi Anabilim Dalı, Hatay-TÜRKİYE 2Fırat Üniversitesi Tıp Fakültesi, Anatomi Anabilim Dalı, Elazığ-TÜRKİYE 3Süleyman Demirel Üniversitesi Tıp Fakültesi Tıbbi Biyoloji ve Genetik Anabilim Dalı, Isparta-TÜRKİYE |
Keywords: Formaldehyde, ω-3 fatty acids, hippocampus, oxidative injury, rat |
In this study, neurotoxic effects of formaldehyde on hippocampus and protective effects of omega-3 (ω-3) fatty acids against these toxic effects were investigated at biochemical level.
For this purpose, 21 adult male Wistar rats were randomly divided into three groups. Rats in group I were used as control. Rats in group II were injected every other day with formaldehyde intraperitoneally. Rats in group III were daily administered ω-3 fatty acid with injection of formaldehyde. At the end of a fourteen-day experimental period, all rats were capitated. Then the brains of rats were removed. The activites of malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were determined in the hippocampus specimens by using spectrophotometric methods. The levels of MDA were significantly increased, SOD and GSH-Px were significantly decreased in rats treated with formaldehyde compared to control. There was a statistically significant decrease in MDA levels and, increase in SOD and GSH-Px levels in rats administered ω-3 fatty acids together with formaldehyde. It was determined that exposure of formaldehyde caused oxidative damage in hippocampus of rats and this damage was prevented by administration of ω-3 fatty acids. |
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