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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
2008, Cilt 22, Sayı 2, Sayfa(lar) 059-064
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Antioxidant Effects Of Omega-3 Fatty Acids on Experimental Formaldehyde Toxicity induced İnjury of Hippocampus
İsmail ZARARSIZ1, İlter KUŞ 2, H.Ramazan YILMAZ3, Evren KÖSE2, Mustafa SARSILMAZ2
1Mustafa Kemal Üniversitesi Tayfur Ata Sökmen Tıp Fakültesi, Anatomi Anabilim Dalı, Hatay-TÜRKİYE
2Fırat Üniversitesi Tıp Fakültesi, Anatomi Anabilim Dalı, Elazığ-TÜRKİYE
3Süleyman Demirel Üniversitesi Tıp Fakültesi Tıbbi Biyoloji ve Genetik Anabilim Dalı, Isparta-TÜRKİYE
Keywords: Formaldehyde, ω-3 fatty acids, hippocampus, oxidative injury, rat

In this study, neurotoxic effects of formaldehyde on hippocampus and protective effects of omega-3 (ω-3) fatty acids against these toxic effects were investigated at biochemical level.

For this purpose, 21 adult male Wistar rats were randomly divided into three groups. Rats in group I were used as control. Rats in group II were injected every other day with formaldehyde intraperitoneally. Rats in group III were daily administered ω-3 fatty acid with injection of formaldehyde. At the end of a fourteen-day experimental period, all rats were capitated. Then the brains of rats were removed. The activites of malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were determined in the hippocampus specimens by using spectrophotometric methods.

The levels of MDA were significantly increased, SOD and GSH-Px were significantly decreased in rats treated with formaldehyde compared to control. There was a statistically significant decrease in MDA levels and, increase in SOD and GSH-Px levels in rats administered ω-3 fatty acids together with formaldehyde.

It was determined that exposure of formaldehyde caused oxidative damage in hippocampus of rats and this damage was prevented by administration of ω-3 fatty acids.


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