In this study, effects of halothane and desflurane anesthesia on some clinical parameters and electrocardiography was investigated in canines. Twenty healthy dogs were used as material. Xylazine and propofol was used for premedication and induction, respectively. Dogs were randomly divided into two groups of 10 dogs each. Group I dogs were anesthetized with halothan, group II dogs were anesthetized with desfluran. Heart and respiratory rate, rectal temperature were recorded before and 15 minutes intervals after induction of anesthesia. Electrocardiographic measurements were also recorded before and every 15 minutes after endotracheal intubation. Electrocardiographic data were found similar in both halothan and desfluran anesthesia. Sinus bradicardia was the most seen aritmic form in both inhalation anesthesia. Atrioventricular blockade was seen in one dog of desflurane group. As a result; with regard to faster and comfortable recovery, desflurane anesthesia was more advantageous than halothane anesthesia.