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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
2009, Cilt 23, Sayı 2, Sayfa(lar) 057-061
[ Turkish ] [ Tam Metin ] [ PDF ]
Protective Efficiency of Caffeic Acid Phenethyl Ester in Carbon Tetracloride-Induced Experimental Lung Injury
Murat ÖGETÜRK1, Neriman ÇOLAKOĞLU2, Murat Abdulgani KUŞ1, İlter KUŞ1, Mustafa SARSILMAZ1
1Fırat Üniversitesi, Tıp Fakültesi, Anatomi Anabilim Dalı, Elazığ, TÜRKİYE
2Fırat Üniversitesi, Tıp Fakültesi, Histoloji-Embriyoloji Anabilim Dalı, Elazığ, TÜRKİYE
Keywords: Caffeic acid phenethyl ester, carbon tetrachloride, lung, rat

In this study, it was aimed to investigate the toxic effects of carbon tetrachloride (CCl4) on the lung tissue using light microscopy. Furthermore, potential protective effects of caffeic acid phenethyl ester (CAPE) against this toxicity were evaluated.

A total of 24 adult male Wistar-albino rats used in our study were divided into three equal groups. The control rats received pure olive oil subcutaneously (sc), rats in the second group were injected with CCl4 (sc) and rats in the third group were injected with CCl4 plus CAPE (intraperitoneally, ip) every other day. At the end of four weeks of experimental period, all animals were killed by decapitation and their lungs were removed. For light microscopic examination, tissue specimens were embedded in paraffin blocks following routine histological procedures. Sections obtained from paraffin blocks were stained with hematoxylen-eosin and examined under a light microscope.

The evaluation of the lung sections of control rats showed normal structural integrity. Epithelial desquamation in the bronchi and bronchioli, interstitial pulmonary hemorrhage, leucocytes with polymorphic nuclei and macrophage infiltration were observed in the lung specimens of rats exposed to CCl4 alone. With exception of small hemorrhagic areas, these histopathological changes were disappeared in rats treated with CCl4 plus CAPE.

In view of the findings of the present microscopic study, it was determined that histopathological changes in the lung tissue resulting from experimental CCl4 toxicity could be prevented by CAPE administration.

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