Crimean-Congo Hemorrhagic Fever (CCHF) is a zoonotic disease tick-borne caused by Crimean- Congo hemorrhagic fever virus (CCHFV), which is a member of the Nairovirus genus family Bunyaviridae. CCHF was first recognized during a large outbreak among agricultural workers in the mid-1940s in the Crimean peninsula. The disease now occurs sporadically throughout much of Africa, Asia, East Europe, Middle East and results in an approximately 30% fatality rate. Humans usually become infected by being bitten by ticks (especially genus Hyalomma), often while working with domestic animals. Contact with blood, secretions or excretions of infected animals or humans may also transmit infection. In 2002, it was defined firstly in the Tokat region of Turkey during an outbreak. In this review, have been remained CCHF of etiology, epidemiology, pathogenesis, clinical signs, diagnosis, treatment, prevention and control methods over.