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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
2013, Cilt 27, Sayı 1, Sayfa(lar) 013-018
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Effects of Selenium and Vitamin E on Glucose, Lipid Values, Platelet Indices and Renal Tissue in Experimental Diabetes
1Harran Üniversitesi, Sağlık Bilimleri Enstitüsü, Fizyoloji Anabilim Dalı, Şanlıurfa, TÜRKİYE
2Harran Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Şanlıurfa, TÜRKİYE
Keywords: Diabetes, glucose, lipids, platelet indices, kidney, rat

Objective: Diabetic agents increasing free radicals may cause oxidative damage in tissues and affects platelet indices. Vitamin E and selenium (Se), which are important antioxidants, may protect harmful effects of the free radicals. In this study, it was aimed to investigate the effects of Se and vitamin E on some biochemical parameters, platelet indices and renal tissue in experimentally induced diabetes.

Material and Methods: This study was performed on Wistar albino rats. The first group was used as a control. The second group was used as diabetes injected 65 mg/kg of streptozotosin (STZ). The third group received with Se (Na2SeO3, 0.3 mg/kg body weight), the fourth group with vitamin E (dl-α-tocopheryl acetate, 100 mg/kg body weight), and the fifth group with Se plus vitamin E combination (Na2SeO3, 0.3 mg/kg body weight+dl-α-tocopheryl acetate, 100 mg/kg body weight) for every other day intervals during fifteen days. Blood and kidney tissue samples of all rats were analyzed 15 days after STZ injection.

Results: The values of glucose, trigliserid, cholesterol and low density lipoprotein were increased in diabetes group; plateletcrit and platelet counts were decreased. The correlation between mean platelet volume and cholesterol was significant in only diabetes group. The levels of glucose, low density lipoprotein and amylase activity were decreased by treatment of the antioxidants. Renal tissues were not affected in diabetes and antioxidant groups.

Conclusion: Se and vitamin E may affect on some platelet indices, glucose concentration and lipid values. Se and vitamin E supplementation in diabetic rats may induce hypolipidemic and hypoglycemic effects, and these antioxidants may be used for prophylactic purpose in diabetes.

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