Objective: Lower urinary tract symptoms (LUTS) are significant symptoms that affect the quality of life in women. Vitamin B₁₂ deficiency is a widespread problem globally. In our study, we evaluated the impact of serum vitamin B₁₂ levels on female LUTS using the International Consultation on Incontinence Questionnaire Female Lower Urinary Tract Symptoms Modules (ICIQ-FLUTS) form.

Materials and Methods: Female patients who visited Internal Medicine outpatient clinic at Elazig Fethi Sekin City Hospital and had their serum B₁₂ levels measured were included in the study. Patients were divided into three groups based on their serum B₁₂ levels: Group 1 with levels 0-199 ng/L, Group 2 with levels 200-299 ng/L, Group 3 with levels 300 ng/L and above. The patients completed the ICIQ-FLUTS form, and results were statistically compared and evaluated.

Results: The mean serum B₁₂ levels were 135.52±38.97 ng/L in Group 1, 253.12±21.59 ng/L in Group 2, and 383.52±62.78 ng/L in Group 3, with an overall average of 257.386±397 ng/L. In ICIQ-FLUTS evaluation results, there was no significant difference among three groups in F score (p=0.503), V score (p=0.726), and I score (p=0.067). However, Post Hoc test revealed a statistically significant difference in I score between Group 1 and 3 (p=0.036) when groups were compared individually.

Conclusion: Our study demonstrated a statistically significant difference in the I score between patients with low vitamin B₁₂ levels and the normal group, indicating that vitamin B₁₂ may also have an influence on voiding physiology and the development of incontinence symptoms.