Laparoscopic appendectomy is a standart procedure for acute appendicitis. Situs inversus is a rare condition in which visceral organs are reversedor mirrored from their normal position. A 19 year-old female patient presented with an acute abdomenal pain and nausea that started one day ago. In x-ray film and ultrasonography, situs inversus totalis and acute appendicitis were detected. aparoscopic appendectomy was completed with success. No intraoperative or postoperative complications occured. Acute appendicitis can be diagnosed accurately by use of medical scans in acute abdominal cases which are not first identified as situs inversus totalis. Medical scans should certainly be used on patients who are having left lower quadrant pain and whose acute abdomen diagnosis can not be clearly defined. Laparoscopic surgery is a safe and easy method be applied by experienced surgeons to situs inversus cases.