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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
2015, Cilt 29, Sayı 2, Sayfa(lar) 057-062
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The Effects of Vitamin D on Changes in Rat's Ovarium Tissues Induced by the Administration of Doxorubicin and Cyclophosphamide
Şeyda YAVUZKIR1, Alpaslan AKYOL1, Tuncay KULOĞLU2
1Fırat Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Elazığ, TÜRKİYE
2Fırat Üniversitesi, Tıp Fakültesi, Histoloji Embriyoloji Anabilim Dalı, Elazığ, TÜRKİYE
Keywords: Rat, cyclophosphamide, doxorubicin, vitamin D

Objective: Due to the incidence and high death rate, cancer is one of the important health problems together with environmental carcinogenic factors today. Cancer is most frequently seen in females. Chemotherapeutic agents such as cyclophosphamide and doxorubicin were administered for the cancers seen in females. Previous studies indicated that these chemotherapeutic agents have an evident effect in germ cells. Vitamin D prevents apoptosis of cells by both inhibiting angiogenesis and proliferative effect. The effect of vitamin D on the damage of ovarium tissue by Cyclophosphamide and doxorubicin is not known yet. In this study, it was aimed to investigate the effects of vitamin D on the changes on rat ovarium tissue and it's function by cyclophosphamide and doxorubicin administration.

Materials and Methods: Thirty-six female rats were used in the study. The rats were divided into six groups including 6 rats each: control group, doxorubicin group, doxorubicin plus vitamin D group, cyclophosphamide group, cyclophosphamide plus vitamin D group and vitamin D group. All rats were decapitated under anesthesia after the experiments. Ovarium tissues were immediately extracted and histopathologic sections were prepared and ovarium reserves were examined.

Results: Whereas ovarium reserve was found as sufficient in control and vitamin D groups, decrease was observed in the ovarium reserves of the other groups. The maximum decrease was seen in cyclophosphamide group.

Conclusion: As a result it was seen that substantial dose of vitamine D had no preventive effect on cytotoxic effect of cyclophosphamide and doxorubicin

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