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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
2018, Cilt 32, Sayı 2, Sayfa(lar) 065-070
[ Turkish ] [ Tam Metin ] [ PDF ]
Platelet Large Cell Ratio Levels in Smoking
Mücahid YILMAZ1, Hidayet KAYANÇİÇEK2, Nevzat GÖZEL3, Mustafa Necati DAĞLI2, Orkun EROĞLU4, Yusuf ÇEKİCİ5, Özlem SEÇEN1, Fikret KELEŞ1, Ökkeş UKU1
1Elazığ Education and Research Hospital Eğitim ve Araştırma Hastanesi, Cardiology Clinic, Elazığ, TURKEY
2Elazığ Medical Park Hospital, Cardiology Clinic, Elazığ, TURKEY
3Firat University, Fırat Medical Center, Department of Internal Medicine, Elazığ, TURKEY
4Elazığ Education and Research Hospital, Ear Nose Throat Clinic, Elazığ, TURKEY
5Dr. Ersin Arslan Education and Research Hospital, Cardiology Clinic, Gaziantep, TURKEY
Keywords: Smoking, platelet volume indices, platelet large cell ratio

Objective: It was reported that smoking promotes endovascular thrombosis by increasing platelet adherence to endothelium and platelet aggregation. It is known that platelet volume indices (PVI) can indicate to increased platelet activity. Therefore, we aimed to evaluate effects of smoking on PVI values in healthy smokers.

Materials and Methods: Two hundred and ninety eight consecutive current smoking, healthy male subjects and two hundred and six age-matched, non-smoking healthy male subjects were enrolled to the study. Complete blood count parameters (especially PVI values), and lipid profile were analyzed in all study participants and persons’ smoking habits were calculated as pack-years.

Results: The study showed that platelet large cell ratio was (PLC-R) significantly higher by smokers compared to the non-smokers. PLC-R and PLCC (Platelet large cell count) values have a moderate degree of positive correlation with pack-year. In multivariate logistic regression analysis it was found that PLC-R levels were independent predictors of smoking (β=0.384, P: 0.03, 95% CI: 0.134 to 2.071). There were no statistically significant differences between two group in terms of other PVI parameters.

Conclusion: Elevated PLC-R level is correlated with cigarette smoking positively and may be a useful indicator of coagulation activity in the smokers.

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