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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
2019, Cilt 33, Sayı 3, Sayfa(lar) 143-147
[ Turkish ] [ Tam Metin ] [ PDF ]
Effects of Systemic Zoledronic Acid Application on Bone Implant Connection of Titanium Implants After The Osseointegration Period
Serkan DÜNDAR1, Alihan BOZOĞLAN1, Tuba TALO YILDIRIM1, Mehmet GÜL2, Mustafa KIRTAY3, Ferhan YAMAN4
1Fırat University, Faculty of Dentistry, Department of Periodontology, Elazığ, TURKEY
2Harran University, Faculty of Dentistry, Department of Periodontology, Şanlıurfa, TURKEY
3Free Dentist, Oral and Maxillofacial Surgery, Toronto, CANADA
4Free Dentist, Oral and Maxillofacial Surgery, Diyarbakır, TURKEY
Keywords: Zoledronic acid, osseointegration, bone implant connection, femoral bone

Objective: This study examined the effects of systemic zoledronic acid (ZA) application on bone implant connection (BIC) of titanium implants after the 4 weeks osseointegration period.

Materials and Methods: Twenty one adult female Wistar albino rats were used in the study. The machined surface titanium implants were surgically integrated in the corticocancellous bone of metaphyseal part of the right femur of the rats. Next, the rats were divided randomly into 3 groups: control (n=7); only titanium implants were integrated in right femoral bones and rats received no further treatment during the 8 weeks experimental period. ZA dose 1 group (n=7); and ZA dose 2 group (n=7). A single dose systemic ZA applications were done in the treatment groups, 0.1 mg/kg and 0.2 mg/kg, respectively after the 4 week osseointegration period. After 4 weeks from the ZA application and 8 weeks of the experimental period, the rats were killed, and the implants and the surrounding bone tissues were harvested, and BIC ratios (%) were analysed according to non-decalcified histological procedures.

Results: Bone implant connection ratio was higher in the ZA treatment groups when compared to the controls (P<0.05), but no statistically significant differences were detected between the treatment groups (P>0.05).

Conclusion: These data suggest that the single dose application of ZA after the osseointegration period could improve BIC.


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