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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
2022, Cilt 36, Sayı 2, Sayfa(lar) 136-143
[ Turkish ] [ Tam Metin ] [ PDF ]
Prevalance of Cardiovascular Autonomic Neuropathy in Patients With Normotensive Type 2 Diabetes Mellitus and Defining Associated Risk Factors
Mehmet TEKİNALP1, Ahmet SOYLU2, Alpay ARIBAŞ2
1Necip Fazil City Hospital, Cardiology Clinic, Kahramanmaraş, TÜRKİYE
2Necmettin Erbakan University, Faculty of Medicine, Department of Cardiology, Konya, TÜRKİYE
Keywords: Cardiovascular autonomic neuropathy, prevalance, risk factors, Type 2 diabetes

Objective: This study aimed to evaluate the prevelance of cardiovascular autonomic neuropathy (CAN), associated risk factors, and the correlation between these risk factors and the progression of CAN in patients with normotensive type 2 diabetes.

Materials and Methods: This study is an observational study including 60 patients with normotensive type 2 diabetes between the ages of 32 and 64 years (mean 49.20±7.44), consisting of 38 women (63.3%) and 22 men (36.7%). All patients are evaluated with standart Ewing Battery tests at baseline and at the end of the first year. Test results are expressed by a scoring system.

Results: CAN prevelance regressed from 78.3% at baseline to 70% at the end of the first year (p=0.245) and Ewing score regressed from 1.50 (1.00-2.50) to 1.00 (0.50-2.00) (p= 0.035). CAN patients were older and had higher SBP at the end of the 12th month (p= 0.037 and p= 0.039, respectively). CAN was associated with age, SBP, and more significantly with lower use of statins (B= 0.12, p= 0.015; B=0.09, p= 0.007; B= -1.83, p=0.052 respectively). Ewing score was significantly correlated with SBP (r=0.38, p=0.034) and near significantly with age, diabetes duration, and HbA1c (r=0.25, p=0.062; r=0.24, p=0.063; r=0.24, p=0.071). Changes in Ewing score was associated only with decreased total cholesterol (B=0.26, p=0.047).

Conclusion: Age, SBP, and total cholesterol levels may be associated with CAN in patients with normotensive type 2 diabetes. There is a need for further studies with different designs.


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