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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
2022, Cilt 36, Sayı 3, Sayfa(lar) 253-258
[ Turkish ] [ Tam Metin ] [ PDF ]
Anti-Inflammatory Effects of Resveratrol on the Radiotherapy-Induced Neuroinflammation
Azibe YILDIZ1, Tuba ÇİFTÇİ2, Seyhan POLAT3, Mehmet GÜNATA3, Hakan PARLAKPINAR3, Öztun TEMELLİ4, Alaadin POLAT5, Nigar VARDI1
1Inonu University, Faculty of Medicine, Department of Histology and Embryology, Malatya, TÜRKİYE
2Inonu University, Faculty of Medicine, Medical Student, Malatya, TÜRKİYE
3Inonu University, Faculty of Medicine, Department of Medical Pharmacology, Malatya, TÜRKİYE
4Inonu University, Faculty of Medicine, Department of Radiation Oncology, Malatya, TÜRKİYE
5Inonu University, Faculty of Medicine, Department of Physiology, Malatya, TÜRKİYE
Keywords: Radiotherapy, resveratrol, neuroinflammation, microglia, autophagy

Objective: Damage in the central nervous system caused by cranial radiotherapy (RT) has been linked to neuroinflammation due to microglial activation. Evidence reveals that resveratrol (RES) exerts neuroprotective effects by inhibiting neuroinflammation. There are limited studies investigating the effects of RES on microglia-related neuroinflammation developed as a result of RT. Therefore, this study was designed to investigate the effects of RES on RT-induced microglial-related neuroinflammation.

Materials and Methods: Rats were simple randomly divided into three groups. Sham (SH) group received ethanol solution on the 1st-14th days of the study. RT group was applied a single dose of total cranial 15 Gy X radiation on the 7th day of the study. RES group was administered a dose of 20 mg/kg on the 1st-14th days of the study and a single dose of total cranial 15 Gy X radiation on the 7th day of the study. The brain tissues removed at the end of the experiment were subjected to histological techniques and procedures for histological and immunohistochemical examinations. The data were evaluated statistically.

Results: RT administration caused histological changes such as neuron degeneration and edema in the brain tissue. In addition, RT administration induced a significant increase in CD68 and tumor necrosis factor-alpha (TNF-α) immunoreactivity. In the RES+RT group, it was observed that histological changes were alleviated, and CD68 and TNF-α immunoreactivities were decreased. In addition, a significant increase in the immunoreactivity of autophagy-related proteins was detected in this group.

Conclusion: Evaluating together all the data, it was revealed that RES attenuates microglia-mediated neuroinflammation and neuronal degeneration.


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