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Fırat University Medical Journal of Health Sciences
2023, Cilt 37, Sayı 3, Sayfa(lar) 243-248
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Evaluation of the Effects of the Systemic Vitamin C Supplementation on Peri-Implant Bone Regeneration and Osseointegration: An Experimental Study
Merve YILMAZ BOZOĞLAN1, Serkan DÜNDAR2, Alihan BOZOĞLAN2, Tuba TALO YILDIRIM2, Erhan Cahit ÖZCAN3, Mustafa KIRTAY4, Can Ayhan KAYA5, Osman HABEK6
1Fırat University, Faculty of Medicine, Department of Pharmacology, Elazig, TURKIYE
2Fırat University, Faculty of Dentistry, Department of Periodontics, Elazig, TURKIYE
3Fırat Üniversitesi, Faculty of Medicine, Department of Plastic, Reconstructive and Aesthetic Surgery, Elazig, TURKIYE
4Private Practice Physician, Oral and Maxillofacial Surgery, Ontario, KANADA
5Dicle University, Diyarbakır Agricultural College, Dairy and Livestock Program, Diyarbakir, TURKIYE
6Private Practice Physician, Oral and Maxillofacial Surgery, Sanliurfa, TURKIYE
Keywords: Osseointegration, bone implant connection, guided bone regeneration, vitamin c, vitamin supplementation

Guided bone regeneration (GBR) is a dental surgical prosedure used to stimulate bone growth in tissue defects adjacent to dental implants. This study purposed to evaluate the effect of dietary supplementation of Vitamin C (Vit C) on the osseointegration and periimplant bone regeneration after implant insertion surgery with GBR. Thirthy Sprague Dawley rats were enrolled in the study and they were divided into 3 groups as control, Vit C 1 and Vit C 2. Two different doses (5 mg/kg and 10 mg/kg) of Vit C were performed to the Vit C 1 and Vit C 2 groups, respectively. Ossoeintegration and periimplant bone tissue regeneration analysed by reverse torque method. No statistically significant difference was observed in the biomechanical reverse torque analysis in the implants of the groups. Although osseointegration was higher numerically in the Vit C 1 group, this was not statistically significant. Vit C supplementation did not increase the osseointegration with GBR (P>0.05) (P:0.920). If the numerical increase in our findings were significant, it may be considered to recommend Vit C supplementation to patients scheduled for implant surgery.

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