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Fırat University Medical Journal of Health Sciences
2023, Cilt 37, Sayı 3, Sayfa(lar) 255-260
[ Turkish ] [ Tam Metin ] [ PDF ]
Whole Blood Viscosity Predicts Amputation in Patients With Lower Extremity Peripheral Arterial Disease
Nail Burak ÖZBEYAZ1, Engin ALGÜL2, Hilal ERKEN PAMUKCU2
1TR Ministry of Health, Pursaklar State Hospital, Cardiology Clinic, Ankara, TURKIYE
2TR Ministry of Health, Etlik City Hospital, Cardiology Clinic, Ankara, TURKIYE
Keywords: Whole blood viscosity, peripheral artery disease, critical limb ischemia, amputation

Objective: This study aims to find the relationship between whole blood viscosity (WBV) and amputation events occurring within 1 year of patients with lower extremity peripheral arterial (LEPAD) disease who cannot be revascularized by surgical or percutaneous methods.

Materials and Methods: The study retrospectively examined the data of 261 LEPAD patients with critical limb ischemia. WBV values of the patients were found with a formulation obtained from the total protein and hematocrit values in the blood samples (Simone’s formula).

Results: Amputation developed in 51 (19.6%) patients. Hemoglobin, hematocrit, white blood cell count, neutrophil, platelet, WBV at high shear rate (HSR) (16.58±2.13 vs. 15.74±1.47, p<0.001) and WBV at low shear rate (LSR) of patients with amputation (100.15±14.97 vs. 92.84±13.39, p=0.002) value was found to be higher. As a result of multivariate regression analysis, WBV at HSR (OR: 1.096 95%CI (1.067-1.182), p=0.002) and WBV at LSR (OR: 6.481 95%CI (4.102-9.486), p<0.001) were found to be independent risk factors indicating the development of amputation. As a result of the receiver operating characteristics curve analysis, the cut-off value showing amputation for WBV at HSR is 16.34 (69% sensitivity, 68.6% specificity, and area under the curve (AUC): 0.728(0.532-0.823), p=0.005), a cut-off value indicating amputation for WBV at LSR is 97.48 (71.5%) sensitivity, specificity of 70.2% and AUC: 0.736(0.551-0.842), p=0.003).

Conclusions: According to the shear rate, both WBV values were found predictive of amputation in patients with critical limb ischemia who could not be revascularized.


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