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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
2009, Cilt 23, Sayı 3, Sayfa(lar) 145-149
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Dişi Ratlarda Ovariektomi Sonrası Vitamin E ve Hormon Replasman Tedavisinin Serum Leptin Düzeylerine Etkisi
Leyla BEYTUR1, Mehmet ŞİMŞEK2, Ekrem SAPMAZ2, Ekrem SAPMAZ2, Abdullah YAŞAR3, Gıyasettin BAYDAŞ3
1Malatya Gözde Hastanesi Kadın Hastalıkları ve Doğum Kliniği, Malatya, TÜRKİYE
2Fırat Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Elazığ, TÜRKİYE
3Fırat Üniversitesi Tıp Fakültesi, Fizyoloji Anabilim Dalı, Elazığ, TÜRKİYE
Keywords: Ovariectomy, estradiol, progesterone, leptin, vitamin E

To evaluate the effects of hormone replacement therapy and vitamin E on weight and serum leptin levels in female rats before and after surgical menopause.

A total of 38 Wistar Albino female rats with an average weight 200 g were divided into five groups randomly; sham group, ovariectomy + saline group, ovariectomy + 17ß–estradiol group, ovariectomy + 17ß–estradiol + progesteron group, ovariectomy + vitamin E group. At the end of the study, blood was taken by decapitation and serum estradiol, progesteron and leptin levels were measured. Kolmogorov Smirnov Z and One Way Anova tests were used in statistical analyses. p < 0.05 was considered statistically significant.

Weight gain in rats after ovariectomy after third month was not significantly higher than the control. However, leptin levels were found to be significantlyu decreased in the ovariectomised group compared to control group. Serum leptin levels were increased significantly in the ovariectomy + estradiol and ovariectomy + estradiol + progesteron groups but decreased in the vitamin E group. No weight change was observed in estradiol, estradiol + progesteron or vitamin E groups.

The decrease in leptin levels after ovariectomy in rats can be prevented by estrogen and/or progesteron treatment. Vitamin E may not prevent the decrease in serum leptin levels due to menopause.


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