We would like to draw attention to ocular involvement and regression with chemotherapy in a young patient with Acute Lenfoblastic Leukemia (ALL) in this case study. Sixteen years old female patient was admitted with loss of vision in right eye obtaining for one month. The patient had diagnosis of ALL for 4 years and and have been on remission for the last one year. Best corrected visual acuity (BCVA) on the right eye was counting fingers from two meters and 10/10 on the left eye. Ocular metastasis of ALL was considered as a result of investigations and anamnesis of patient. Systemic chemotherapy was started again and after a few days, visual acuity improved to 2/10 on snellen acuity.