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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
2012, Cilt 26, Sayı 2, Sayfa(lar) 083-085
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Sistosel ve Stres İnkontinansta Polypropylene Mesh Sonuçları
Cüneyt Eftal TANER, İlkan KAYAR, Ömer BAŞOĞUL, Gülin OKAY, Ayşe Gül KEBAPCILAR
İzmir Ege Doğumevi ve Kadın Hastalıkları Eğitim ve Araştırma Hastanesi, Kadın Doğum Hastalıkları, İzmir, TÜRKİYE
Anahtar Kelimeler: Polypropylene dörtkollu mesh, sistosel, stres inkontinans
Özet
Amaç: Sistosel ve stres inkontinans saptanan olgularda kullanılan polypropylene mesh sonuçlarının değerlendirilmesi.

Gereç ve Yöntem: Çalışma grubunu sistosel ile birlikte stres inkontinans saptanan 26 olgu oluşturdu. Internatinal Continence Society (ICS) sınıflamasına göre sistoselleri evre 2 veya daha fazla idi. Tüm olgulara rutin testler ile birlikte ürodinamik incelemeler yapıldı. Tüm olgularda 4 kollu polypropylene mesh ile midüretra ve mesane desteği sağlandı. Postoperatif 1. ayda ICIQ-SF doldurtuldu. Hastalar postoperatif komplikasyonlar açısından 1 yıl takip edildi.

Bulgular: Yirmi altı olgunun yaş ortalaması 52.3±11, postoperatif ortalama takip süresi 13.1±8.7 ay idi. Postoperatif sistosel rekurrensi veya stres inkontinans semptomları izlenmedi. Post operatif başarı oranı %100 olarak kabul edildi. Üç olguda (%11.5) vaginal erozyon, iki olguda (%7.7) disparauni, iki olguda uyluk ağrısı ve bir olguda genitofemoral alandaki giriş yerinde enfeksiyon ve sinus formasyonu izlendi. ICIQ-SF skorları 14.9±2.4'den postoperatif 1. ayda 5.2±4.7'ye düştü (p< 0.01).

Sonuç: Sistosel ve stres inkontinanslı olgularda tek bir polypropylene mesh ile mesane ve midüretra takviyesi başarılı, etkili, düşük morbiditeli ve iyi tolere edilen bir yöntem olarak kabul edilebilir.

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    Classical Anterior colporrhaphy operation which is used for cystocele is associated with an unacceptably high recurrence rate. Paravaginal repairs are technically more difficult to perform and may be associated with more complications. Because of these reasons mesh use has become more prevalent for anterior vaginal operations1.

    In recent years, transobturator techniques which are accepted as less invasive operations, subtitude for invasive- Tension-free vaginal tape (TVT) operations. In this study, we presented four arm polypropylene mesh operation results that is used to support bladder and midurethral defects in patients suffering from grade-II or more cystocele and stress urinary incontinence.

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    The study group included 26 cases who have grade- II or more cystocele with stress urinary incontinence. Patients having cystocele with stage 2 or more according to Internatinal Continence Society (ICS) classification, were included in the study group2. All patients underwent a complete urologic, gynecologic and urodynamic work-up before the surgical treatment. Patients with complaints of stress incontinence or mixed incontinence were included into the study group. Furthermore patients having first degree uterine prolapsus and/or rectocele were also included. Patients with urge incontinence or mixed incontinence having urge symptoms were excluded.

    Four arm polypropylene macropore mesh ( Nasca, Promedon, Arjantina) has been used for all cases. Vaginal mucosa peel off from bladder by median incision that began just beneath 1.5 cm from the urethra. Outside-in transobturatory procedure were used for lateral arms to pass the fasia. Fore arms of the mesh were passed subcutaneously through lateral sides of the urethra and they were hooked to suprapubic region. Bladder and midurethra were reinforced by the mesh. Finally one part of vaginal mucosa were cauterized and sutured via the double-breasted technic.

    During the surgery antibiotic prophylaxis was administered via single 1g intravenous dose of cefozoline. Patients were discharged at postoperative day one after removal of the urinary catheter and observing no residual urine within the bladder. Followup visits were performed at 1, 3 and 6 months postoperatively.

    Operation was accepted as succesful when there were no cystocele or only stage 1 cystocele. Improvement was defined as a significant reduction in urine leakage, such that it did not require further treatment. ICIQ-SF filled by the patients were compared preoperatively and at postoperative first month.

    Statistical analysis
    Results are expressed as mean+SD. Pre- and posttreatment values of the parameters were compared with a paired sample t-test. The relationships between different variables were analysed with Pearson correlation test. The statistical analysis was carried out by using Statistical Package for the Social Sciences (SPSS), version 11.0 (SPSS, Chicago, IL). A p-value of 0.05 was considered to be statistically significant.

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    Twenty-six patients completed the study protocol. The follow-up period was 1 year for post-operative complications and ICIQ-SF scores were recorded at one month. The study was approved by the local ethics committee. Mean age was 52,3 ± 11,0 years (range, 36- 71 years). Mean follow-up period was 13,1±8,7 months (range 1-29 month). Preoperative mean ICIQ-SF scores were 14,9 ± 2,4 at postoperative period mean score 5,2 ± 4,7 significantly decreased (p < 0,01) .

    We used four arm polypropylene monofilament macroporous mesh for supporting the bladder and midurethra in all patients. At the same time 3 patients had rectosel so posterior colpoperinearaphy procedure were added. Bladder, urethra or vascular complications didn't occur. In our study, the surgical cure rate was found 100% for cytocele repair and for stres urinary incontinence.

    Vulvar ecchymosis was encountered in a patient at post operative period. We found regional ache at point of mesh arm entry in two patients. Two other patients had dysparaunia and mesh tension at vaginal sulcus. During the postoperative follow-up period three patients had erosion at the level of midurehtral incision (11,5%). We resected mesh partially and the redundant mucosa was excised then the mucosa re- sutured. Infection and sinus formation was detected at genitofemoral fold trocar insertion point in one patient, (Table 1). In this case local excision was performed and medication was administered.


    Büyütmek İçin Tıklayın
    Table 1: Postoperative complication in 26 patients.

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    Vaginal anterior repairing and Kelly plication is the classical procedure for treatment of cystocele3. Central defects are generally repaired via fasial plication. In addition to these operations, paravaginal reinforcement and Burch colposuspesion can be used4. However, this procedure needs laparotomy which extends hospitalization during this operation. Vaginal operations are preferred because of short hospitalization period and with minimal morbidity5.

    Severe cystocele repair should include correction of bladder herniation and without obstruction and retention. Tension-free mesh is placed under the bladder wall and resistance to intrabdominal pressure is increased at the same time with permenant reinforcement of bladder basement,neck and side walls6.

    We didn't detect any recurrence of symptomatic cystocele or stage 1 cystocele after operation in our 26 patients with stage 2 or more cystocele. ICIQ-SF scores significantly decreased in the postoperative period (14.9±2.4 versus 5.2±4.7) in our study group (p < 0,01). Flood et al.7 assessed the use of Marlex mesh in conjunction with anterior colporrhaphy for the correction of cystocele with or without urinary stress incontinence in 142 patients. Their mean follow-up time was 3.2 years.

    No patients experienced recurrent anterior vaginal wall prolapse but three of their patients (2.1%) developed mesh erosions in the vagina. There was a 74% success rate in the treatment of urinary stress incontinence. In our study we had also three patients with vaginal erosions (11.5%). Since, initially we had no enough experience with this technique in our hospital, a relatively high complication rate appeared in our study.

    Yan et al.8 studied cystocele repair by the placement of a synthetic subvesical mesh secured anteriorly through the obturator foramen in 30 patients. They only found failure in a young patient (3%) after a mean follow-up of 6.7 months. Two vaginal erosions (7%) were observed at six and nine months postoperatively. Two cases (14%) complained of anterior dysparaunia.

    Granese et al.9, repaired moderate or severe cystocele with Y-shaped mesh placed on the perivesical fascia. After a follow-up of 24 months,19 patients (11%) reported recurrent cystocele, 9 patients (5.1%) had a vaginal wall erosion after 6 month follow up and 2 patients (1%) complained of persistent dyspareunia. Palanca et al.10, used polypropylene mesh for the treatment of cystocele in 31 cases whose mean age was 62.3 year. They found no patient with prolapse recurrence.

    Park et al.11 reported success rate of cystocele repair as 90% and stress incontinence was cured in all patients (100%). The postoperative complication was transient voiding difficulty in 2 cases after mean follow up 7.1 month in.

    The use of mesh in operations isn't always safe. Cicatrix formation and erosion rate was reported to be 6% in some series12,13. Infection, pain, seroma, fıstula and sinus formation were reported to be other complications in mesh operations. Type 1 monofilament polypropylene macroporous mesh should be preferred because of low complication rates13.

    As a conclusion, the use of one piece of polypropylene mesh for the support of bladder and midurethra in cases with combined cystocele and stres urinary incontinence may be accepted as a successful, effective method of treatment with low morbidity and well tolerebility.

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    1) Nguyen JN. The use of grafts for anterior vaginal prolapse repair:pros and cons. Current Opin Obstet Gynecol 2008; 20: 501-505.

    2) Weber AM, Abrams P, Brubaker L, Cundiff G. et al. The standardization of terminology for researchers in female pelvic floor disorders. Int Urogynecol J 2001; 12: 178-186.

    3) Kelly HA, Dumm WM. Urinary incontinance in women without manifest injury to the bladder. 1914. Int Urogynecol J Pelvic Floor Dysfunct 1998; 9: 158-164.

    4) Burch JC. Urethrovaginal fixation to Cooper's ligament for correction of stres incontinance, cystocele and prolapse. Am J Obstet Gynecol 1961; 81: 281-290.

    5) Raz S, Little NA, Juma S, Sussman EM. Repair of severe anterior wall prolapse grade IV cystourethrocele. J Urol 1991; 146: 988-992.

    6) Migliari R, Usai E. Treatment results using a mixed fiber mesh in patients with grade IV cystocele. J Urol 1999; 161: 1255-1258.

    7) Flood CG, Drutz HP, Waja L. Anterior colporrhaphy reinforced with Marlex mesh for the treatment of cystoceles. Int Urogynecol J Pelvik Floor Dysfunct 1998; 9: 200-204.

    8) Yan A, Anne M, Karine A, et al. Cystocele repair by a synthetic vaginal mesh secured anteriorly through the obturator foramen. Eur J Obstet Gynecol Reprod Biol 2004; 15: 115: 90-94.

    9) Granese R, Adile B. Tension free cystocele repair: an analysis after a follow up of 24 months. Minerva Gynecol 2007; 59: 369-376.

    10) Palanca BA, Perez CF, Zaragoza QJA, et al. Cystocele repair with a polypropylene mesh: our experience. Arch Esp Urol 2004; 54: 391-396.

    11) Park HK, Paick SH, Lee BK, et al. Initial experience with concomitant prolif system and tension free vaginal tape procedures in patients with stres urinary incontinence and cystocele. INJ 2010; 14: 43-47.

    12) Debodinance P, Delporte P, Engrand JB, Boulogne M. Development of better tolerated prosthetic materials: applications in gynecolgical surgery. J Gynecol Obstet Biol Reprod 2002; 31: 527-540.

    13) Cosson M, Debodinance P, Boukerrou M, et al. Mechanical properties of synthetic implants used in the repair of prolapse and urinary incontinance in women which is the ideal material? Int Urogynecol J Pelvic Floor Dysfunct 2003; 14: 169-178.

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