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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
2022, Cilt 36, Sayı 1, Sayfa(lar) 046-050
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Can TGF-Β1 Be an Important Prognostic Factor in Predicting Covid-19 Disease Severity?
Mustafa TİMURKAAN1, Hakan AYYILDIZ2, Mehmet KALAYCI3
1Fethi Sekin City Hospital, Internal Medicine Clinic, Elazığ, TÜRKİYE
2Fethi Sekin City Hospital, Biochemistry Laboratory, Elazığ, TÜRKİYE
3Akçakoca State Hospital, Biochemistry Laboratory, Düzce, TÜRKİYE
Keywords: TGFβ1, Covid19, pandemy, fibrosis

Objective Covid-19, which causes an ongoing worldwide epidemic, affects millions of people with the emergence of its variant forms. This study aims to compare the levels of Transforming growth factor β1 (TGFβ1), which can be associated with disease severity in Covid-19 physiopathology, in patients and healthy population, and to determine whether it can be used as a prognostic and predictive marker.

Materials and Methods: 43 mild [CT (Computed tomography) (-), Female=21-Male=22)], 45 severe [CT (+), Female=20-Male=25)] Covid-19 patients classified according to the disease severity constituted the experimental group of our study. In addition, 88 healthy (Female=46-Male=42) people comprised the control group.

Results: We found a significant increase in TGFβ1, CRP, and D-Dimer levels in the Covid-19 compared to the control group. We found a positive correlation between TGFβ1 levels and CRP levels in the patient group.

Conclusion: Although efforts to end the pandemic with antiviral drug and vaccine options continue all over the world, the final treatment for Covid-19 infection has yet been not found. It has been understood that TGFβ1 levels may be the key molecule for the disease and its pathophysiology in patients diagnosed with Covid-19. We believe that this may be a marker for early diagnosis in terms of the severe course of the disease.


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