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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
2002, Cilt 16, Sayı 3-4, Sayfa(lar) 323-328
[ Turkish ] [ PDF ]
Lymphedema after Treatment of Breast Cancer: Anatomy and Pathophysiology
Erhan AYGEN, Cemalettin CAMCI, Osman DOĞRU
Fırat Üniversitesi Tıp Fakültesi Genel Cerrahi Anabilim Dalı Elazığ / TÜRKİYE
Keywords: Breast cancer, lymphedema, anatomy, pathophsiology

Lymphatic flow begins lymphatic capillars which is consisting only endothelial layer in the connective tissue, and goes through to the anatomic plexus and common lymphatic channels. There are superficial and deep lymphatic systems that is seperated by fascia in hand, arm and forearm. This two lymphatic systems join in the axilla and go through to the jugulo-subclavian venous junction by subclavian lymphatic vessel and also drain into the venous system.

Lymphedema is hypertrophy of the dermis and hypodermis and progressive pathologic conditions which is characterized chronic inflammatory fibrosis. There are two types of lymphedema which are primary and secondary causes. The most common cause of secondary lymphedema is in the arm which is seen after breast cancer therapy. Pathophysiology of the lymphedema after mastectomy is not clearly understood. It is thought that lympathic system could be damaged after surgical- and/or radio-therapy. Surgical ligations, transsections, and resections of lymphatic vessels, fibrozis of the lymphatics, lymph nodes and surrounding tissue due to radiation are responsible from this damage. However, infections, and unexplained factors like venous and arterial reasons are also responsible in the pathophysiology.


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