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Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi
2021, Cilt 35, Sayı 1, Sayfa(lar) 062-067
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The Effect of Preemptive Intravenous Ibuprofen on Postoperative Opioid Consumption in Patients for Double Jaw Surgery: A Randomized Double-blind Placebo Controlled Study
İrem ATES1, Ümit ERTAŞ2, Muhammed Enes AYDIN1, Ahmet Murat YAYIK1, Zehra BEDİR3, Sara SALCAN4
1Atatürk University, Faculty of Medicine, Anesthesiology and Reanimation Department, Erzurum, TURKIYE
2Atatürk University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Erzurum, TURKIYE
3Erzurum City Hospital, Department of Anesthesiology and Reanimation, Erzurum, TURKIYE
4Binali Yıldırım University, Faculty of Medicine, Public Health Care Department, Erzincan, TURKIYE
Keywords: Double Jaw Surgery, Ibuprofen, preemptive analgesia, postoperative analgesia

Objective: The effect of intravenous ibuprofen preemptively administered in pain management after double jaw surgery are limited.The purpose of the present study was to investigate the effects of preemptive intravenous ibuprofen on postoperative analgesia and opioid consumption in patients who undergo double jaw surgery (DJS).

Materials and Methods: After ethical committee approval, 48 patients, American Society of Anesthesiologist (ASA) I-II, scheduled for DJS were randomly assigned into two groups. The ibuprofen group (n=24) received 800 mg IV ibuprofen in 100 mL saline, while the control group (n=24) received 100 mL saline, thirty minutes before the surgery. All patients were administered 1.000 mg iv paracetamol 30 minutes before the surgery ended and was repeated every 6 hours. Postoperative analgesia was performed with patient controlled analgesia (PCA). The pain of the groups was evaluated with Visual Analog Scale (VAS), and the total opioid consumption was recorded at the end of 24 hours.

Results: VAS scores of the patients were compared with the Control Group, the VAS scores were significantly lower in the ibuprofen group at 1st, 2nd, 4th, 8th, 12th and 24th hours (P<0.05). The total opioid consumption was found to be statistically higher in the control group than in the ibuprofen group (326.04 μcg and 163.95 μcg, P<0.05). The need for additional analgesics was more in the control group than in the Ibuprofen Group (14/24, 6/24). Nausea and vomiting were statistically more in the control group (P<0.05). No significant differences were detected between the groups in terms of hemorrhage (P>0.05).

Conclusion: Preemptive IV Ibuprofen may be one of the alternative analgesic drugs which might be used in DJS.


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